Accelerated epigenetic aging in Down syndrome
نویسندگان
چکیده
منابع مشابه
Accelerated epigenetic aging in Down syndrome
Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we utilize a quantitative molecular marker of aging (known as the epigenetic clock) to demonstrate th...
متن کاملAccelerated epigenetic aging in Werner syndrome
Individuals suffering from Werner syndrome (WS) exhibit many clinical signs of accelerated aging. While the underlying constitutional mutation leads to accelerated rates of DNA damage, it is not yet known whether WS is also associated with an increased epigenetic age according to a DNA methylation based biomarker of aging (the "Epigenetic Clock"). Using whole blood methylation data from 18 WS c...
متن کاملAging and Down Syndrome
1Department of Molecular and Biomedical Pharmacology, Sanders-Brown Center on Aging, University of Kentucky, 800 South Limestone Street, Lexington, KY 40536, USA 2Kennedy Krieger Institute, Johns Hopkins University School of Medicine, 707 N. Broadway, Baltimore, MD 21205, USA 3Eleanor Roosevelt Institute and the Department of Biological Sciences, University of Denver, 2101 E. Wesley Avenue, Den...
متن کاملAn Epigenetic Clock Measures Accelerated Aging in Treated HIV Infection.
In this issue of Molecular Cell, Gross et al. (2016) find a CpG DNA methylation signature in blood cells of patients with chronic well-controlled HIV infection that correlates with accelerated aging.
متن کاملIs schizophrenia a syndrome of accelerated aging?
Schizophrenia is associated with a number of anatomical and physiological abnormalities outside of the brain, as well as with a decrease in average life span estimated at 20% in the United States. Some studies suggest that this increased mortality is not entirely due to associated causes such as suicide and the use of psychotropic medications. In this article, in order to focus greater attentio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Aging Cell
سال: 2015
ISSN: 1474-9718,1474-9726
DOI: 10.1111/acel.12325